2-(Pyridin-3-yl)-1H-benzimidazole → HCID 49832602, compound

HRID 1945795Notes

Reaction equation

HRID 1945795 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:3]=1.[N:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]2[NH:39][C:38]3[CH:40]=[CH:41][CH:42]=[CH:43][C:37]=3[N:36]=2)[CH:30]=1>>[CH3:11][N:8]1[C:7]([CH2:12][N:13]2[CH2:14][CH2:15][CH:16]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:17][CH2:18]2)=[N:6][C:5]2[C:9]1=[N:10][C:2]([N:36]1[C:37]3[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=3[N:39]=[C:35]1[C:31]1[CH:30]=[N:29][CH:34]=[CH:33][CH:32]=1)=[N:3][C:4]=2[N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 2476352-(Pyridin-3-yl)-1H-benzimidazoleHCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 49832602HCID 49832602, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol and 2-(pyridin-3-yl)-1H-benzo[d]imidazole were reacted to give 219. LCMS m/z: 568.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b1c266e6e9b84bc3869997ba1033c702
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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