2-methyl-1,2-dihydroindazol-3-one → HCID 49832603, compound

HRID 1945796Notes

Reaction equation

HRID 1945796 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:3]=1.[CH3:29][N:30]1[C:38](=[O:39])[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[NH:31]1>>[OH:22][C:19]([CH:16]1[CH2:17][CH2:18][N:13]([CH2:12][C:7]2[N:8]([CH3:11])[C:9]3[C:5]([N:6]=2)=[C:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[N:3]=[C:2]([N:31]2[C:32]4[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=4)[C:38](=[O:39])[N:30]2[CH3:29])[N:10]=3)[CH2:14][CH2:15]1)([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 5905132-methyl-1,2-dihydroindazol-3-oneHCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 49832603HCID 49832603, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol and 2-methyl-1,2-dihydroindazol-3-one were reacted to give 220. LCMS m/z: 521.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ba96fd0d202a43f181736d26d38e6ef4
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

Loading…