2-(Oxolan-2-yl)-1H-benzimidazole → HCID 59605243, compound

HRID 1945800Notes

Reaction equation

HRID 1945800 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][CH:16]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:15][CH2:14]3)[N:8]2[CH3:11])=[C:4]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:3]=1.[O:29]1[CH2:33][CH2:32][CH2:31][CH:30]1[C:34]1[NH:38][C:37]2[CH:39]=[CH:40][CH:41]=[CH:42][C:36]=2[N:35]=1>>[CH3:11][N:8]1[C:7]([CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19]([OH:22])([CH3:21])[CH3:20])[CH2:15][CH2:14]2)=[N:6][C:5]2[C:9]1=[N:10][C:2]([N:35]1[C:36]3[CH:42]=[CH:41][CH:40]=[CH:39][C:37]=3[N:38]=[C:34]1[CH:30]1[CH2:31][CH2:32][CH2:33][O:29]1)=[N:3][C:4]=2[N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 31113932-(Oxolan-2-yl)-1H-benzimidazoleHCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 59605243HCID 59605243, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol and 2-(tetrahydrofuran-2-yl)-1H-benzimidazole were reacted to give 224. LCMS m/z: 561.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0886126ca16f4091984104efdfa788a2
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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