2-Methylbenzimidazole → HCID 59605817, compound

HRID 1945807Notes

Reaction equation

Cl[C:2]1[N:3]=[C:4]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)[CH2:14][CH2:13]3)=[C:8]([CH3:24])[C:6]=2[N:7]=1.[CH3:31][C:32]1[NH:36][C:35]2[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=2[N:33]=1>>[CH3:24][C:8]1[C:6]2[N:7]=[C:2]([N:33]3[C:34]4[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=4[N:36]=[C:32]3[CH3:31])[N:3]=[C:4]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:5]=2[S:10][C:9]=1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[CH2:14][CH2:13]1

Participants

Reactant 2

HCID 119842-Methylbenzimidazole

HCID 86648247HCID 86648247, compound

Product 1

HCID 59605817HCID 59605817, compound

Procedure

Following General Procedure I for Buchwald coupling, 4-(1-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)morpholine and 2-methyl-1H-benzo[d]imidazole were reacted to give 232. LCMS: M+H+=548.3

Workup

customwere reacted

Sources & evidence

ORD record: ord-1a024e1cb5d040b48887095f023ffd48
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394796B2

Reaction notes

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