3-methoxy-1H-indazole → HCID 59605777, compound

HRID 1945809Notes

Reaction equation

HRID 1945809 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH3:23])([CH3:22])[C:19]([NH2:21])=[O:20])[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH3:30][O:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[NH:34][N:33]=1>>[CH3:30][O:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[N:34]([C:2]2[N:3]=[C:4]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:5]3[S:10][C:9]([CH2:11][N:12]4[CH2:13][CH2:14][N:15]([C:18]([CH3:23])([CH3:22])[C:19]([NH2:21])=[O:20])[CH2:16][CH2:17]4)=[CH:8][C:6]=3[N:7]=2)[N:33]=1

Participants

3

Reactant 2

HCID 5195813-methoxy-1H-indazoleHCID 574940122-(4-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

Product 1

HCID 59605777HCID 59605777, compound

Procedure

2-(4-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide (0.1 g) was reacted with 3-methoxy-1H-indazole via General Procedure I for Buchwald coupling give 16.4 mg 234 following reverse phase purification. MS (Q1) 507.2 (M)+

Workup

  1. customcoupling give
  2. custom16.4 mg 234 following reverse phase purification

Sources & evidence

ORD record
ord-6ce57ee6c8754c0e9150480cbfee1962
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

Loading…