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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1945814Generated: November 1, 2026

2-cyclobutyl-1H-Benzimidazole → 2-(1-((2-(2-cyclobutyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

https://huagongshe.com/reaction/1945814

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-cyclobutyl-1H-BenzimidazoleHCID 13415796—
Reactant2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olHCID 59603426—
Product2-(1-((2-(2-cyclobutyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olHCID 59605911—

Reaction Steps

Following General Procedure I for Buchwald coupling, 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol and 2-cyclobutylbenzimidazole were reacted to give 237. LCMS m/z: 545.3 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394796B2
Source datasetuspto-grants-2013_03
ORD IDord-1e48035ba7a64829bfebe810b208600d
Source noteuspto-grants-2013_03