2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol → HCID 59606058, compound

HRID 1945830Notes

Reaction equation

HRID 1945830 reaction equation
[F:1][C:2]1([C:6]2[NH:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=2)[CH2:5][O:4][CH2:3]1.Cl[C:16]1[N:24]=[C:23]2[C:19]([N:20]=[C:21]([CH2:26][N:27]3[CH2:32][CH2:31][CH:30]([C:33]([OH:36])([CH3:35])[CH3:34])[CH2:29][CH2:28]3)[N:22]2[CH3:25])=[C:18]([N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)[N:17]=1>>[F:1][C:2]1([C:6]2[N:7]([C:16]3[N:24]=[C:23]4[C:19]([N:20]=[C:21]([CH2:26][N:27]5[CH2:32][CH2:31][CH:30]([C:33]([OH:36])([CH3:35])[CH3:34])[CH2:29][CH2:28]5)[N:22]4[CH3:25])=[C:18]([N:37]4[CH2:38][CH2:39][O:40][CH2:41][CH2:42]4)[N:17]=3)[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[N:10]=2)[CH2:3][O:4][CH2:5]1

Participants

3

Reactant 2

HCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-olHCID 67492844HCID 67492844, compound

Product 1

HCID 59606058HCID 59606058, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-(3-fluorooxetan-3-yl)-1H-benzimidazole and 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol were reacted to give 262. LCMS m/z: 565.3 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6919d7a4b21c4114939e1aff3dfcf5dd
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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