HCID 12720691, compound → HCID 59605638, compound

HRID 1945841Notes

Reaction equation

HRID 1945841 reaction equation
Br[CH2:2][C:3]1[N:4]([CH3:28])[C:5]2[C:10]([N:11]=1)=[C:9]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[N:8]=[C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])[N:6]=2.[C@H:29]12[CH2:35][C@H:32]([CH2:33][CH2:34]1)[CH2:31][CH:30]2[NH2:36]>>[CH3:28][N:4]1[C:3]([CH2:2][NH:36][CH:30]2[CH2:31][C@H:32]3[CH2:35][CH:29]2[CH2:34][CH2:33]3)=[N:11][C:10]2[C:5]1=[N:6][C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])=[N:8][C:9]=2[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 12720691HCID 12720691, compoundHCID 596058124-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

Product 1

HCID 59605638HCID 59605638, compound

Procedure

4-(8-(Bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine (50 mg) was reacted with (1R,4S)-bicyclo[2.2.1]heptan-2-amine via General Procedure E to give 16 mg of 272 following reverse phase purification. MS (Q1) 473.3 (M)+

Workup

  1. customto give
  2. custom16 mg of 272 following reverse phase purification

Sources & evidence

ORD record
ord-bfa78f9b310f4ede9a60d6b0a39d8d8b
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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