1-Aminocyclopentanemethanol → HCID 59605992, compound

HRID 1945843Notes

Reaction equation

HRID 1945843 reaction equation
Br[CH2:2][C:3]1[N:4]([CH3:28])[C:5]2[C:10]([N:11]=1)=[C:9]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[N:8]=[C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])[N:6]=2.[NH2:29][C:30]1([CH2:35][OH:36])[CH2:34][CH2:33][CH2:32][CH2:31]1>>[CH3:28][N:4]1[C:3]([CH2:2][NH:29][C:30]2([CH2:35][OH:36])[CH2:34][CH2:33][CH2:32][CH2:31]2)=[N:11][C:10]2[C:5]1=[N:6][C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])=[N:8][C:9]=2[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 663071-AminocyclopentanemethanolHCID 596058124-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

Product 1

HCID 59605992HCID 59605992, compound

Procedure

4-(8-(Bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine (50 mg) was reacted with (1-aminocyclopentyl)methanol via General Procedure E to give 10.2 mg of 274 following reverse phase purification. MS (Q1) 477.2 (M)+

Workup

  1. customto give
  2. custom10.2 mg of 274 following reverse phase purification

Sources & evidence

ORD record
ord-5ea5af75766f49b48cd3326bef15cce2
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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