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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1945922Generated: October 26, 2026

2-Methylbenzimidazole → 8-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decane

https://huagongshe.com/reaction/1945922

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethylbenzimidazoleHCID 11984—
Reactant8-((2-Chloro-9-methyl-6-morpholino-9h-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decaneHCID 87421166—
Product8-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decaneHCID 59605207—

Reaction Steps

Following General Procedure I for Buchwald coupling, 8-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-1-oxa-8-azaspiro[4.5]decane and 2-methybenzimidazole were reacted to give 370. LCMS m/z: 503.2 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394796B2
Source datasetuspto-grants-2013_03
ORD IDord-b2aaafb732a9471e9596838d9b2e52f5
Source noteuspto-grants-2013_03