2-Methylbenzimidazole → HCID 59605464, compound

HRID 1945924Notes

Reaction equation

HRID 1945924 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[C:12]1[N:20]=[C:19]2[C:15]([N:16]=[C:17]([CH2:22][N:23]3[CH2:33][CH2:32][C:26]4([C:30](=[O:31])[NH:29][CH2:28][CH2:27]4)[CH2:25][CH2:24]3)[N:18]2[CH3:21])=[C:14]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[N:13]=1>>[CH3:21][N:18]1[C:17]([CH2:22][N:23]2[CH2:24][CH2:25][C:26]3([C:30](=[O:31])[NH:29][CH2:28][CH2:27]3)[CH2:32][CH2:33]2)=[N:16][C:15]2[C:19]1=[N:20][C:12]([N:3]1[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=[C:2]1[CH3:1])=[N:13][C:14]=2[N:34]1[CH2:35][CH2:36][O:37][CH2:38][CH2:39]1

Participants

3

Reactant 2

HCID 119842-MethylbenzimidazoleHCID 86648259HCID 86648259, compound

Product 1

HCID 59605464HCID 59605464, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and 8-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-2,8-diazaspiro[4.5]decan-1-one were reacted to give 379. LCMS m/z 258.6 (2M+H+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f8fca65dbad84f7b99dd47d94d460598
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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