2-Methylbenzimidazole → HCID 59605781, compound

HRID 1945941Notes

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[C:12]1[N:20]=[C:19]2[C:15]([N:16]=[C:17]([CH2:22][N:23]3[CH2:33][CH2:32][C:26]4([O:31][CH2:30][CH2:29][CH2:28][O:27]4)[CH2:25][CH2:24]3)[N:18]2[CH3:21])=[C:14]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[N:13]=1>>[CH3:21][N:18]1[C:17]([CH2:22][N:23]2[CH2:24][CH2:25][C:26]3([O:27][CH2:28][CH2:29][CH2:30][O:31]3)[CH2:32][CH2:33]2)=[N:16][C:15]2[C:19]1=[N:20][C:12]([N:3]1[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=[C:2]1[CH3:1])=[N:13][C:14]=2[N:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1

Participants

Reactant 2

HCID 119842-Methylbenzimidazole

HCID 86648264HCID 86648264, compound

Product 1

HCID 59605781HCID 59605781, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and 9-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-1,5-dioxa-9-azaspiro[5.5]undecane were reacted to give 400. LCMS m/z: 519.2 (MH+)

Workup

customwere reacted

Sources & evidence

ORD record: ord-3e9d5410e6a0408ab333e61d7c7fff01
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394796B2

Reaction notes

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