2-Methylbenzimidazole → HCID 59605255, compound

HRID 1945946Notes

Reaction equation

HRID 1945946 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[C:12]1[N:20]=[C:19]2[C:15]([N:16]=[C:17]([CH2:22][N:23]3[CH2:28][CH2:27][N:26]4[CH2:29][CH2:30][CH2:31][CH:25]4[CH2:24]3)[N:18]2[CH3:21])=[C:14]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[N:13]=1>>[CH2:24]1[N:23]([CH2:22][C:17]2[N:18]([CH3:21])[C:19]3[C:15]([N:16]=2)=[C:14]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[N:13]=[C:12]([N:3]2[C:4]4[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=4[N:6]=[C:2]2[CH3:1])[N:20]=3)[CH2:28][CH2:27][N:26]2[CH2:29][CH2:30][CH2:31][C@@H:25]12

Participants

3

Reactant 2

HCID 119842-MethylbenzimidazoleHCID 87421174HCID 87421174, compound

Product 1

HCID 59605255HCID 59605255, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and racemic 4-(2-chloro-8-((hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methyl)-9-methyl-9H-purin-6-yl)morpholine were reacted. The enantiomers were separated by SFC to give 415. LCMS m/z: 488.2 (MH+)

Workup

  1. customwere reacted
  2. customThe enantiomers were separated by SFC

Sources & evidence

ORD record
ord-4d0df384e18240c6bc1c1208057be7ed
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

Loading…