HCID 53393484, compound → HCID 59605900, compound

HRID 1945955Notes

Reaction equation

HRID 1945955 reaction equation
Br[CH2:2][C:3]1[N:4]([CH3:28])[C:5]2[C:10]([N:11]=1)=[C:9]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[N:8]=[C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])[N:6]=2.[CH3:29][C:30]1([OH:37])[CH2:36][CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH3:29][C:30]1([OH:37])[CH2:36][CH2:35][CH2:34][N:33]([CH2:2][C:3]2[N:4]([CH3:28])[C:5]3[C:10]([N:11]=2)=[C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:8]=[C:7]([N:18]2[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[N:20]=[C:19]2[CH3:27])[N:6]=3)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 53393484HCID 53393484, compoundHCID 596058124-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

Product 1

HCID 59605900HCID 59605900, compound

Procedure

Following General Procedure E for Displacement of alkyl bromide with amines, 4-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine and 4-methylazepan-4-ol were reacted to give 429. [M+H]+ 491.6

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d862a197e5074495b5e6ae4f0db385dd
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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