2-Ethylbenzimidazole → HCID 59605852, compound

HRID 1945965Notes

Reaction equation

[CH2:1]([C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[CH3:2].Cl[C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH:30]4[CH2:33][CH2:32][CH2:31]4)[CH2:26][CH2:25]3)[N:19]2[CH3:22])=[C:15]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[N:14]=1>>[CH:30]1([N:27]2[CH2:26][CH2:25][N:24]([CH2:23][C:18]3[N:19]([CH3:22])[C:20]4[C:16]([N:17]=3)=[C:15]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)[N:14]=[C:13]([N:7]3[C:6]5[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=5[N:4]=[C:3]3[CH2:1][CH3:2])[N:21]=4)[CH2:29][CH2:28]2)[CH2:33][CH2:32][CH2:31]1

Participants

Reactant 2

HCID 158072-Ethylbenzimidazole

HCID 86648266HCID 86648266, compound

Product 1

HCID 59605852HCID 59605852, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-ethylbenzimidazole and 4-(2-chloro-8-((4-cyclobutylpiperazin-1-yl)methyl)-9-methyl-9H-purin-6-yl)morpholine were reacted to give 444. LCMS m/z: 516.3 (MH+)

Workup

customwere reacted

Sources & evidence

ORD record: ord-73467150b6db4727951b5ea39b1a353a
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394796B2

Reaction notes

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