Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-1-[[2-(trimethylsilanyl)ethoxy]methyl]-benzimidazole | HCID 59752898 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Benzimidazole | HCID 5798 | — |
Reaction Steps
2-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole (0.5 g) was placed in a flask with azetidine (0.48 mL), Hunig's base (iPr2Net, 1.5 mL) in 1 mL of ethanol. The reaction was heated to 50° C. overnight and then concentrated to dryness to get 0.55 g of crude 2-(azetidin-1-yl)-1-(2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08394796B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-f80b3f18970240eaa31eab86969933e5 |
|---|
| Source note | uspto-grants-2013_03 |
|---|
