Benzimidazole → HCID 59605403, compound

HRID 1945985Notes

Reaction equation

HRID 1945985 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH:2]=1.[C:10]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]2[N:22]([CH3:37])[C:23]3[C:28]([N:29]=2)=[C:27]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:26]=[C:25](Cl)[N:24]=3)[CH2:16][CH2:15]1)([CH3:13])([CH3:12])[CH3:11].[F:38][CH:39]([F:43])[C:40](O)=O>>[C:10]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]2[N:22]([CH3:37])[C:23]3[C:28]([N:29]=2)=[C:27]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:26]=[C:25]([N:1]2[C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[N:3]=[C:2]2[C:39]([F:43])([F:38])[CH3:40])[N:24]=3)[CH2:16][CH2:15]1)([CH3:13])([CH3:12])[CH3:11]

Participants

4

Reactant 3

HCID 5798BenzimidazoleHCID 9788Difluoroacetic acidHCID 596054704-(8-((4-tert-butylpiperazin-1-yl)methyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine

Product 1

HCID 59605403HCID 59605403, compound

Procedure

Following General Procedure J for Multi-Step Benzimidazole formation, 4-(8-((4-tert-butylpiperazin-1-yl)methyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine was converted to 463 with difluoroacetic acid. LCMS: M+H+=554.3

Sources & evidence

ORD record
ord-bf1cd256068f48eda2571d50e941c526
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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