Phenylacetylene → 7-Diethylamino-3-(4-phenyl-[1,2,3]triazol-1-yl)-chromen-2-one

HRID 19460Notes

Reaction equation

HRID 19460 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([N:15]=[N+:16]=[N-:17])[C:10](=[O:14])[O:11]2)=[CH:6][CH:5]=1)[CH3:2].[C:20]1([C:26]#[CH:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:18]([N:3]([CH2:1][CH3:2])[C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[C:9]([N:15]3[CH:27]=[C:26]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[N:17]=[N:16]3)[C:10](=[O:14])[O:11]2)=[CH:6][CH:5]=1)[CH3:19]

Participants

3

Reactant 2

HCID 10821PhenylacetyleneHCID 58971806HCID 58971806, compound

Product 1

HCID 589718057-Diethylamino-3-(4-phenyl-[1,2,3]triazol-1-yl)-chromen-2-one

Procedure

This example illustrates the fluorogenic conjugation of 7-diethylamino-3-azidocoumarin and phenylacetylene to form 7-diethylamino-3-(4-phenyl-[1,2,3]triazol-1-yl)-chromen-2-one.

Sources & evidence

ORD record
ord-5fe75548be3b4eb5a719ebad0f0d6847
Source dataset
uspto-grants-2010_06
Patent number
US07745229B2

Reaction notes

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