HRID1946010

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1084419

2-cyclopropyl-1H-benzimidazole

C10H10N2

结构：CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3n2C)CC1

HCID86648267

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)(C)N1CCN(Cc2nc3c(N4CCOCC4)nc(-n4c(C5CC5)nc5ccccc54)nc3n2C)CC1

HCID59606061

未命名化合物

PROCEDURE

实验过程

Following General Procedure I for Buchwald coupling, 2-cyclopropylbenzimidazole and ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate were reacted to give 500. LCMS m/z: 588.4 (MH+)

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-627e16e5914144bfbfaa5111362f764c
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394796B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH:1]1([C:4]2[NH:5][C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1.Cl[C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([C:31]([CH3:38])([CH3:37])[C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:27][CH2:26]3)[N:20]2[CH3:23])=[C:16]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[N:15]=1>>[CH:1]1([C:4]2[N:5]([C:14]3[N:22]=[C:21]4[C:17]([N:18]=[C:19]([CH2:24][N:25]5[CH2:26][CH2:27][N:28]([C:31]([CH3:37])([CH3:38])[C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:29][CH2:30]5)[N:20]4[CH3:23])=[C:16]([N:39]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[N:15]=3)[C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1