2-cyclopropyl-1H-1,3-benzodiazole → ethyl 2-(4-((2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate

HRID 1946010Notes

Reaction equation

HRID 1946010 reaction equation
[CH:1]1([C:4]2[NH:5][C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1.Cl[C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([CH2:24][N:25]3[CH2:30][CH2:29][N:28]([C:31]([CH3:38])([CH3:37])[C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:27][CH2:26]3)[N:20]2[CH3:23])=[C:16]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[N:15]=1>>[CH:1]1([C:4]2[N:5]([C:14]3[N:22]=[C:21]4[C:17]([N:18]=[C:19]([CH2:24][N:25]5[CH2:26][CH2:27][N:28]([C:31]([CH3:37])([CH3:38])[C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:29][CH2:30]5)[N:20]4[CH3:23])=[C:16]([N:39]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[N:15]=3)[C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10844192-cyclopropyl-1H-1,3-benzodiazoleHCID 86648267ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate

Product 1

HCID 59606061ethyl 2-(4-((2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate

Procedure

Following General Procedure I for Buchwald coupling, 2-cyclopropylbenzimidazole and ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate were reacted to give 500. LCMS m/z: 588.4 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-627e16e5914144bfbfaa5111362f764c
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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