HRID1946014

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID90097

Methyl 2-bromo-2-methylpropionate

C5H9BrO2

结构：Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCNCC3)n(C)c2n1

HCID59605636

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C(C)(C)N1CCC(Cc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)CC1

HCID59605359

未命名化合物

PROCEDURE

实验过程

Following General Procedure C, 2-bromo-2-methyl-propionoic acid methyl ester and 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine were reacted to give 507. LCMS m/z: 274.2 (2M+H)

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7b2e4c29bb348e7978455ec2a37171c
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394796B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH3:1][O:2][C:3](=[O:8])[C:4](Br)([CH3:6])[CH3:5].[CH3:9][N:10]1[C:18]([CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:17][C:16]2[C:11]1=[N:12][C:13]([N:32]1[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=3[N:34]=[C:33]1[CH3:41])=[N:14][C:15]=2[N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:5][C:4]([N:23]1[CH2:22][CH2:21][CH:20]([CH2:19][C:18]2[N:10]([CH3:9])[C:11]3[C:16]([N:17]=2)=[C:15]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:14]=[C:13]([N:32]2[C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=4[N:34]=[C:33]2[CH3:41])[N:12]=3)[CH2:25][CH2:24]1)([CH3:6])[C:3]([O:2][CH3:1])=[O:8]