Methyl 2-bromo-2-methylpropionate → methyl 2-methyl-2-(4-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)piperidin-1-yl)propanoate

HRID 1946014Notes

Reaction equation

HRID 1946014 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4](Br)([CH3:6])[CH3:5].[CH3:9][N:10]1[C:18]([CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:17][C:16]2[C:11]1=[N:12][C:13]([N:32]1[C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=3[N:34]=[C:33]1[CH3:41])=[N:14][C:15]=2[N:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:5][C:4]([N:23]1[CH2:22][CH2:21][CH:20]([CH2:19][C:18]2[N:10]([CH3:9])[C:11]3[C:16]([N:17]=2)=[C:15]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:14]=[C:13]([N:32]2[C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=4[N:34]=[C:33]2[CH3:41])[N:12]=3)[CH2:25][CH2:24]1)([CH3:6])[C:3]([O:2][CH3:1])=[O:8]

Participants

3

Reactant 2

HCID 90097Methyl 2-bromo-2-methylpropionateHCID 596056364-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine

Product 1

HCID 59605359methyl 2-methyl-2-(4-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)piperidin-1-yl)propanoate

Procedure

Following General Procedure C, 2-bromo-2-methyl-propionoic acid methyl ester and 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine were reacted to give 507. LCMS m/z: 274.2 (2M+H)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d7b2e4c29bb348e7978455ec2a37171c
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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