2-Bromo-2-methylpropanamide → 2-methyl-2-(4-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)piperidin-1-yl)propanamide

HRID 1946015Notes

Reaction equation

HRID 1946015 reaction equation
Br[C:2]([CH3:7])([CH3:6])[C:3]([NH2:5])=[O:4].[CH3:8][N:9]1[C:17]([CH2:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:16][C:15]2[C:10]1=[N:11][C:12]([N:31]1[C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=3[N:33]=[C:32]1[CH3:40])=[N:13][C:14]=2[N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[CH3:6][C:2]([N:22]1[CH2:21][CH2:20][CH:19]([CH2:18][C:17]2[N:9]([CH3:8])[C:10]3[C:15]([N:16]=2)=[C:14]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[N:13]=[C:12]([N:31]2[C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=4[N:33]=[C:32]2[CH3:40])[N:11]=3)[CH2:24][CH2:23]1)([CH3:7])[C:3]([NH2:5])=[O:4]

Participants

3

Reactant 2

HCID 1012352-Bromo-2-methylpropanamideHCID 596056364-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine

Product 1

HCID 596058262-methyl-2-(4-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)piperidin-1-yl)propanamide

Procedure

Following General Procedure C, 2-bromo-2-methyl-propionamide and 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine were reacted to give 508. LCMS m/z: 532.2 (MH+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-06bcdd4a571f43ac90cf215b62eb8b59
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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