2-Ethylbenzimidazole → HCID 59606180, compound

HRID 1946038Notes

Reaction equation

[CH2:1]([C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[CH3:2].Cl[C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([CH2:23][N:24]3[CH2:27][CH:26]([OH:28])[CH2:25]3)[N:19]2[CH3:22])=[C:15]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[N:14]=1>>[CH2:1]([C:3]1[N:4]([C:13]2[N:21]=[C:20]3[C:16]([N:17]=[C:18]([CH2:23][N:24]4[CH2:25][CH:26]([OH:28])[CH2:27]4)[N:19]3[CH3:22])=[C:15]([N:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)[N:14]=2)[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1)[CH3:2]

Participants

Reactant 2

HCID 158072-Ethylbenzimidazole

HCID 86648268HCID 86648268, compound

Product 1

HCID 59606180HCID 59606180, compound

Procedure

Following General Procedure I for Buchwald coupling, 2-ethylbenzimidazole and 1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)azetidin-3-ol were reacted to give 524. LCMS m/z: 449.2 (MH+)

Workup

customwere reacted

Sources & evidence

ORD record: ord-1f6dd62ba6964df985f719e2fa12a710
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394796B2

Reaction notes

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