Aluminium lithium hydride → HCID 59605995, compound

HRID 1946052Notes

Reaction equation

HRID 1946052 reaction equation
[CH2:1]([C:3]1[N:7]([C:8]2[N:16]=[C:15]3[C:11]([N:12]=[C:13]([CH2:18][CH:19]4[CH2:22][N:21]([C:23]([CH3:29])([CH3:28])[C:24](OC)=[O:25])[CH2:20]4)[N:14]3[CH3:17])=[C:10]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[N:9]=2)[C:6]2[CH:36]=[CH:37][CH:38]=[CH:39][C:5]=2[N:4]=1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([C:3]1[N:7]([C:8]2[N:16]=[C:15]3[C:11]([N:12]=[C:13]([CH2:18][CH:19]4[CH2:20][N:21]([C:23]([CH3:29])([CH3:28])[CH2:24][OH:25])[CH2:22]4)[N:14]3[CH3:17])=[C:10]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[N:9]=2)[C:6]2[CH:36]=[CH:37][CH:38]=[CH:39][C:5]=2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 59605445methyl 2-(3-((2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)azetidin-1-yl)-2-methylpropanoate

Product 1

HCID 59605995HCID 59605995, compound

Procedure

Following the procedure for 509, methyl 2-(3-((2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)azetidin-1-yl)-2-methylpropanoate was reduced with lithium aluminum hydride to give 533. LCMS m/z: 253.2 (2M+H+)

Sources & evidence

ORD record
ord-9edf24463f274257ac73ca7b5fffd1c6
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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