2-Bromopropanamide → HCID 59605858, compound

HRID 1946062Notes

Reaction equation

HRID 1946062 reaction equation
[NH:1]1[CH2:4][CH:3]([CH2:5][C:6]2[N:7]([CH3:32])[C:8]3[C:13]([N:14]=2)=[C:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:11]=[C:10]([N:21]2[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[N:23]=[C:22]2[CH2:30][CH3:31])[N:9]=3)[CH2:2]1.Br[CH:34]([CH3:38])[C:35]([NH2:37])=[O:36]>>[CH2:30]([C:22]1[N:21]([C:10]2[N:9]=[C:8]3[C:13]([N:14]=[C:6]([CH2:5][CH:3]4[CH2:2][N:1]([C@@H:34]([CH3:38])[C:35]([NH2:37])=[O:36])[CH2:4]4)[N:7]3[CH3:32])=[C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[N:11]=2)[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=1)[CH3:31]

Participants

3

Reactant 2

HCID 1011182-BromopropanamideHCID 596052818-Azetidin-3-ylmethyl-2-(2-ethylbenzoimidazol-1-yl)-9-methyl-6-morpholin-4-yl-9H-purine

Product 1

HCID 59605858HCID 59605858, compound

Procedure

Following General Procedure C, 4-(8-(azetidin-3-ylmethyl)-2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-9H-purin-6-yl)morpholine and 2-bromopropionamide were reacted to give a racemic mixture. The enantiomers were separated by SFC to give 546. LCMS m/z: 252.7 (2M+H+)

Workup

  1. customwere reacted
  2. customto give a racemic mixture
  3. customThe enantiomers were separated by SFC

Sources & evidence

ORD record
ord-24cfc1e8961e4ef69ac6c7089dabcc3c
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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