5-(Bromomethyl)-1,2-oxazole → HCID 59605951, compound

HRID 1946083Notes

Reaction equation

HRID 1946083 reaction equation
[CH3:1][N:2]1[C:10]([CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:9][C:8]2[C:3]1=[N:4][C:5]([N:24]1[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[N:26]=[C:25]1[CH3:33])=[N:6][C:7]=2[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.Br[CH2:35][C:36]1[O:40][N:39]=[CH:38][CH:37]=1>>[O:40]1[C:36]([CH2:35][N:15]2[CH2:16][CH2:17][CH:12]([CH2:11][C:10]3[N:2]([CH3:1])[C:3]4[C:8]([N:9]=3)=[C:7]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[N:6]=[C:5]([N:24]3[C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=5[N:26]=[C:25]3[CH3:33])[N:4]=4)[CH2:13][CH2:14]2)=[CH:37][CH:38]=[N:39]1

Participants

3

Reactant 2

HCID 100349035-(Bromomethyl)-1,2-oxazoleHCID 596056364-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine

Product 1

HCID 59605951HCID 59605951, compound

Procedure

Following General Procedure C, 4-(9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-8-(piperidin-4-ylmethyl)-9H-purin-6-yl)morpholine and 5-(bromomethyl)isoxazole were reacted to give 570. LCMS m/z: 264.7 (2M+H+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d29f1152fde24ce0b34aaf1baa212a82
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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