2-Bromo-N,2-dimethylpropanamide → HCID 59605417, compound

HRID 1946093Notes

Reaction equation

HRID 1946093 reaction equation
[NH:1]1[CH2:4][CH:3]([CH2:5][C:6]2[N:7]([CH3:31])[C:8]3[C:13]([N:14]=2)=[C:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:11]=[C:10]([N:21]2[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[N:23]=[C:22]2[CH3:30])[N:9]=3)[CH2:2]1.Br[C:33]([CH3:39])([CH3:38])[C:34]([NH:36][CH3:37])=[O:35]>>[CH3:37][NH:36][C:34](=[O:35])[C:33]([CH3:39])([N:1]1[CH2:2][CH:3]([CH2:5][C:6]2[N:7]([CH3:31])[C:8]3[C:13]([N:14]=2)=[C:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[N:11]=[C:10]([N:21]2[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[N:23]=[C:22]2[CH3:30])[N:9]=3)[CH2:4]1)[CH3:38]

Participants

3

Reactant 2

HCID 2875602-Bromo-N,2-dimethylpropanamideHCID 596054598-Azetidin-3-ylmethyl-2-(2-methylbenzoimidazol-1-yl)-9-methyl-6-morpholin-4-yl-9H-purine

Product 1

HCID 59605417HCID 59605417, compound

Procedure

Following General Procedure C, 4-(8-(azetidin-3-ylmethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine and 2-bromo-N,2-dimethylpropanamide were reacted to give 580. LCMS m/z: 259.7 (2M+H+)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b7a7a32ce5e24a2ba087398126815bad
Source dataset
uspto-grants-2013_03
Patent number
US08394796B2

Reaction notes

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