反应详情

Z-Glu(Val-Gly-OBzl)-OBzl described above (6.20 g, 10.03 mmol) was suspended in ethanol (200 ml), 10% palladium/carbon (1.50 g) was added to the suspension, and a reduction reaction was performed under a hydrogen atmosphere at 55° C. for 5 hours. During the reaction, 100 ml in a total volume of water was gradually added. The catalyst was removed by filtration using a Kiriyama funnel, and the filtrate was concentrated under reduced pressure to a half volume. The reaction solution was further filtered through a membrane filter, and the filtrate was concentrated under reduced pressure. After the residue was dissolved in a small volume of water, ethanol was added to precipitate a crystal, and the crystal was collected by filtration and dried under reduced pressure to obtain γ-Glu-Val-Gly as a white powder (2.85 g, 9.40 mmol).

1. customa reduction reaction
2. additionwas gradually added
3. customThe catalyst was removed by filtration
4. concentrationthe filtrate was concentrated under reduced pressure to a half volume
5. filtrationThe reaction solution was further filtered through a membrane
6. filtrationfilter
7. concentrationthe filtrate was concentrated under reduced pressure
8. dissolutionAfter the residue was dissolved in a small volume of water, ethanol
9. additionwas added
10. customto precipitate a crystal
11. filtrationthe crystal was collected by filtration
12. customdried under reduced pressure