Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-Chloro-5-(4-methyl-piperazin-1-yl)-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-Chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile | HCID 59138987 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 3-Chloro-5-(4-methyl-piperazin-1-yl)-benzoic acid | HCID 59139045 | — |
반응 단계
To 3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile (1.4 g, 5.9 mmol) dissolved in ethanol (10 ml) was added 2M NaOH (20 ml) and reaction mixture was heated at reflux for 20 hours. The mixture was reduced in vacuo and the crude product was acidified in 1N HCl to pH 6 and partitioned between EtOAc and H2O. The organic layer was evaporated to dryness in vacuo to give 0.7 g of the title compound as a white solid (LC/MS: Rt 1.67, [M+H]+ 256, acidic method).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08399442B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-98c88d4299be47f993e5e71809f7e745 |
| 출처 메모 | uspto-grants-2013_03 |