Diethyl Ether → HCID 178477739, compound

HRID 1946290Notes

Reaction equation

HRID 1946290 reaction equation
[CH:1]1([NH:4][C:5]([NH:7][C:8]2[C:9]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][C:20]([CH2:22][N:23]5[CH2:28][CH2:27][O:26][CH2:25][CH2:24]5)=[CH:21][C:15]=4[N:14]=3)=[N:10][NH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH2:29]([S:31]([OH:34])(=[O:33])=[O:32])[CH3:30].CCOCC>CO.CCOC(C)=O.CO>[CH2:29]([S:31]([OH:34])(=[O:33])=[O:32])[CH3:30].[CH:1]1([NH:4][C:5]([NH:7][C:8]2[C:9]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][C:20]([CH2:22][N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)=[CH:21][C:15]=4[N:14]=3)=[N:10][NH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 11668Ethanesulfonic acidHCID 178522431HCID 178522431, compound

Product 1

HCID 178477739HCID 178477739, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21584119Ethylacetate methanolSolvent

Procedure

To a solution of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea free base in MeOH-EtOAc was added 1 equivalent of ethanesulfonic acid. The mixture was stirred at ambient temperature and then reduced in vacuo. The residue was taken up in MeOH and to the solution was added Et2O. Mixture left to stand for 72 h and the solid formed collected by filtration and dried to give 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea ethanesulfonate salt.

Workup

  1. waitMixture left
  2. customthe solid formed
  3. filtrationcollected by filtration
  4. customdried

Sources & evidence

ORD record
ord-e3a7d5aa020e47278228302997993632
Source dataset
uspto-grants-2013_03
Patent number
US08399442B2

Reaction notes

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