HCID 59547844, compound → HCID 59547885, compound

Participants

Reaction Steps

A solution of N-[1-({2-chloro-5-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide (for a preparation see Example 5)(2.44 g, 5.38 mmol) in ethyl acetate (50 ml) was added to 10% palladium on carbon (wet) (0.585 g, 0.275 mmol) under vacuum. The mixture was hydrogenated at ambient temperature for 2 h. A further amount of 10% palladium on carbon wet (0.79 g) was added and the reaction was stirred for a further 2 h. The reaction mixture was filtered using a 10 g celite cartridge. The filtrate was concentrated in vacuo to leave a brown solid (2.01 g). The residue was preabsorbed on florosil and purified on silica (100 g×2) using 0-100% ethyl acetate-cyclohexane. The appropriate fractions were combined and evaporated in vacuo to give the title compound as a white foam (1.24 g); LCMS: (System 4) MH+=364, tRET=2.42 min.

Provenance & Evidence