Sodium Hydroxide → HCID 59547946, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4-[(3-{[(2,6-difluorophenyl)carbonyl]amino}-1H-pyrazol-1-yl)methyl]-3-(trifluoromethyl)benzoate (for a preparation see Example 43)(0.773 g, 1.71 mmol) in methanol (20 ml) was added 2 M aqueous sodium hydroxide (5 ml, 10 mmol). The solution was heated to 60° C. under air for 45 min. The solvent was removed at reduced pressure and the residue dissolved in water (50 ml). The solution was acidified using 2M HCl aqueous (10 ml). The suspension was diluted with ethyl acetate (50 ml) and the phases separated. The aqueous phase was extracted with ethyl acetate (25 ml). The combined organic extracts were dried (MgSO4), filtered and the solvent removed in vacuo to give the title compound as a white solid (0.666 g); LCMS: (System 4) MH+=426, tRET=2.48 min.

Provenance & Evidence