反应详情

To a solution of methyl 5-(phenyloxy)-2-(trifluoromethyl)benzoate (0.504 g, 1.70 mmol) in ethanol (20 ml), was added 2 M aqueous sodium hydroxide (2.0 ml, 4 mmol). The solution was stirred and left to stand overnight. The solvent was evaporated in vacuo. The residue was dissolved in water and diluted with aqueous 2 M HCl. The mixture extracted with chloroform and the phases separated using a hydrophobic frit. The solvent was removed in vacuo to give a colourless oil (0.540 g). The residue was dissolved in chloroform and dried (Na2SO4), filtered and the solvent removed in vacuo to give the title compound as a colourless oil (0.519 g); LCMS: (System 4) (M-H)−=281, tRET=2.84 min.

1. waitleft
2. customThe solvent was evaporated in vacuo
3. dissolutionThe residue was dissolved in water
4. additiondiluted with aqueous 2 M HCl
5. extractionThe mixture extracted with chloroform
6. customthe phases separated
7. customThe solvent was removed in vacuo