Riboflavin → HCID 59547994, compound

Participants

Reaction Steps

To 10% palladium on activated carbon degussa type E101 NE/W (wet) (440 mg, 4.14 mmol, Aldrich) was added a slight suspension of the 2,6-difluoro-N-(1-{[5-nitro-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (for a preparation see Intermediate 40) (2.0 g, 4.69 mmol) in a solution of ethanol (80 ml) under vacuum. A further amount of 10% palladium on activated carbon degussa type E101 NE/W (wet) (0.2 g) was added after 2 h. The suspension was hydrogenated for a total of 4 h at ambient temperature. The suspension was filtered and the residue washed with ethanol (50 ml). The solvent was removed in vacuo to leave a pale yellow foam (1.79 g); LCMS: (System 4) MH+=397, tRET=2.65 min.

Provenance & Evidence