Riboflavin → N-{1-[(5-amino-2-methylphenyl)methyl]-1H-pyrazol-3-yl}-2,6-difluorobenzamide

Participants

Reaction Steps

To 10% palladium on activated carbon degussa type E101 NE/W (wet) (280 mg) was added a slight suspension of 2,6-difluoro-N-{1-[(2-methyl-5-nitrophenyl)methyl]-1H-pyrazol-3-yl}benzamide (for a preparation see Intermediate 47)(1.27 g, 3.41 mmol) in a mixture of ethyl acetate (20 ml) and ethanol (50 ml) under vacuum. The suspension was hydrogenated for 1.5 h at ambient temperature. The suspension was filtered and the residue washed with methanol (30 ml). The solvent was removed in vacuo to leave a white solid (1.09 g); LCMS (System 4) MH+=343, tRET=1.43 min.

Provenance & Evidence