HCID 46945201, compound → HCID 59548023, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,6-difluoro-N-(1-{[5-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)benzamide (for a preparation see Example 102)(80 mg, 0.158 mmol) in THF (1 ml) was added tetrakis(triphenyl-phosphine)palladium(0) (25 mg, 0.022 mmol, Aldrich). To the solution was added 2.0 M methylzinc chloride in THF (0.5 mL, 1.0 mmol, Aldrich) and the mixture stirred at 80° C. under nitrogen for 4 h. The solvent was removed in vacuo and the residue diluted with methanol:DMSO (1:1, 2 ml). The suspension was filtered and purified by MDAP on Sunfire C18 column (Method B) using Acetonitrile-Water with a Formic acid modifier. The solvent was evaporated in vacuo to give the title compound as a white solid (26.3 mg); LCMS: (System 4) MH+=396, tRET=3.00 min.

Provenance & Evidence