Hydrazine → 6-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 1946447Notes

Reaction equation

HRID 1946447 reaction equation
[CH3:1][CH:2]([CH3:10])[C:3](=O)[CH2:4][CH2:5][C:6](O)=[O:7].[NH2:11][NH2:12]>C(O)C>[CH:2]([C:3]1[CH2:4][CH2:5][C:6](=[O:7])[NH:11][N:12]=1)([CH3:10])[CH3:1]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 389345-Methyl-4-oxohexanoic acid

Product 1

HCID 230280926-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Methyl-4-oxohexanoic acid (3.60 g, 25.0 mmol) and anhydrous hydrazine (0.80 g, 26.0 mmol) were heated for 3 hours in ethanol (36.0 ml) under stirring. After the reaction solution was concentrated under reduced pressure, hexane was added to the residues to precipitate crystals, and the crystals were collected by filtration to give 4,5-dihydro-6-isopropyl-3(2H)-pyridazinone as crystals. The yield was 3.10 g.

Workup

  1. concentrationAfter the reaction solution was concentrated under reduced pressure, hexane
  2. additionwas added to the residues
  3. customto precipitate crystals
  4. filtrationthe crystals were collected by filtration

Sources & evidence

ORD record
ord-89ea518887624acea03f3b30dd12e99f
Source dataset
uspto-grants-2013_03
Patent number
US08399381B2

Reaction notes

Loading…