Ethylamine → HCID 23028136, compound

HRID 1946460Notes

Reaction equation

HRID 1946460 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7](Cl)=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13].[CH2:16]([NH2:18])[CH3:17]>C(#N)C>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([NH:18][CH2:16][CH3:17])=[N:6][N:5]2[C:11]=1[S:12]([NH2:15])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 14422383HCID 14422383, compound

Product 1

HCID 23028136HCID 23028136, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2,6-Dichloroimidazo[1,2-b]pyridazin-3-ylsulfonamide (2.00 g, 7.50 mmol) and ethylamine (50%, 10.0 ml) were stirred in acetonitrile (100 ml) at 70° C. for 8 hours. The reaction mixture was concentrated to dryness, dissolved in ice-water (50.0 ml), and adjusted to pH 6 with conc. hydrochloric acid. The precipitated crystals were filtered and washed with water to give the title compound as pale yellow crystals. The yield was 1.10 g (53.3%).

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. dissolutiondissolved in ice-water (50.0 ml)
  3. filtrationThe precipitated crystals were filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-f9d7484b3602446bb993a611cbe366d8
Source dataset
uspto-grants-2013_03
Patent number
US08399381B2

Reaction notes

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