HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-methylethyl)cyclohepta[d]imidazol-4(1H)-one → 2-(1-methylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-methylethyl)cyclohepta[d]imidazol-4(1H)-one | HCID 11687025 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1-methylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one | HCID 58460222 | 100.8% |
Reaction Steps
A solution of Intermediate 1 (3.4 g) in methanol (700 mL) was hydrogenated using the H-Cube (settings: room temp, 1.4 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was concentrated under vacuum to give the title compound (3.5 g). LC/MS MH+ 193, Rt 0.42 min (2 minute run).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399444B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f32e9b7499154f05b514594c08511f4f |
| Source note | uspto-grants-2013_03 |