反应详情

Intermediate 5 (94 mg) was dissolved in methanol (2 ml) and treated with sodium hydroxide, 2 M aq. (2 ml). The RM was left in solution for 1 hour. The RM was concentrated under vacuum. The residue was purified by MDAP (Method A). The desired fractions were combined and concentrated under nitrogen blowdown to give the title compound (53 mg). LC/MS MH+ 361, Rt 1.63 min (5 minute run).

1. concentrationThe RM was concentrated under vacuum
2. customThe residue was purified by MDAP (Method A)
3. concentrationconcentrated under nitrogen