Sodium borohydride → HCID 58460144, compound

Participants

Reaction Steps

Sodium borohydride (76 mg) was added to a stirred solution of Intermediate 18 (290 mg) in dichloromethane (3 ml) and methanol (3 ml). The reaction mixture was stirred for 3 hours. The reaction mixture was concentrated under vacuum, partitioned between EtOAc (20 ml) and water (15 ml). The two phases were separated and the aqueous phase was extracted again with EtOAc (2×10 ml). The phases were separated, the organic extracts were combined, dried (hydrophobic frit) and concentrated under vacuum to give the title compound (272 mg). LC/MS MH+ 291, Rt 1.35 min (5 minute run).

Provenance & Evidence