Sodium Hydroxide → HCID 67434998, compound

HRID 1946488Notes

Reaction equation

HRID 1946488 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:13]3[CH:14]([C:17](C(OCC)=O)(C(OCC)=O)[C:18]([O:20]CC)=[O:19])[CH2:15][CH2:16][C:12]=3[N:11]=[C:10]2[CH:33]([CH3:35])[CH3:34])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[NH3:9].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]2[C:13]3[CH:14]([CH2:17][C:18]([OH:20])=[O:19])[CH2:15][CH2:16][C:12]=3[N:11]=[C:10]2[CH:33]([CH3:35])[CH3:34])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58460151HCID 58460151, compound

Product 1

HCID 67434998HCID 67434998, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Intermediate 20 (50 mg) was dissolved in methanol (3 ml) and the resulting soln. was treated with sodium hydroxide, 3M aq. (1 ml). The resulting suspension was heated to reflux for 4 hr. The reaction mixture was allowed to cool and concentrated in vacuo. The crude residue was taken up in acetic acid (10 ml) and heated to reflux for 2 h.

Workup

  1. temperatureThe resulting suspension was heated
  2. temperatureto reflux for 4 hr
  3. temperatureto cool
  4. concentrationconcentrated in vacuo
  5. temperatureheated
  6. temperatureto reflux for 2 h.

Sources & evidence

ORD record
ord-9e691efde5e7405687032ec42ac446b6
Source dataset
uspto-grants-2013_03
Patent number
US08399444B2

Reaction notes

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