Sodium borohydride → HCID 58460192, compound

Participants

Reaction Steps

Sodium borohydride (155 mg) was added to a stirred solution of Intermediate 21 (660 mg) in dichloromethane (2 mL) and methanol (2 mL). The reaction mixture was stirred for 2.5 hours. More sodium borohydride (155 mg) was added. The RM was left stirring at room temp. under nitrogen for 1 hour. The reaction mixture was partitioned between EtOAc (50 ml) and water (30 ml). The two phases were separated and the aqueous phase was extracted again with EtOAc (30 ml). The phases were separated; the organic extracts were combined, dried (hydrophobic frit) and concentrated under vacuum to give the title compound (660 mg). LC/MS MH+ 325, 327, Rt 1.63 min (5 minute run).

Provenance & Evidence