1,2-Dichloroethane → HCID 58460184, compound

Participants

Reaction Conditions

Reaction Steps

Benzyl alcohol (0.193 mL), DMAP (16.96 mg) and EDC (195 mgl) were successively added to a stirring solution of Example 9 (340 mg) in dichloromethane (5 mL) cooled at 0° C. under nitrogen. The RM was warmed to room temp and left stirring under nitrogen atm. overnight. The reaction mixture was partitioned between dichloromethane (10 mL) and water (10 mL). The aqueous phase was again extracted with DCM (20 ml). The 2 phases were separated; the organic extract was dried (hydrophobic frit) and concentrated under vacuum. The residue was purified on silica using a cyclohexane:ethyl acetate 0-100% gradient. The desired fractions were combined and concentrated under vacuum to give the title compound (380 mg). LC/MS MH+ 457, 459, Rt 3.55 min (5 minute run).

Provenance & Evidence