Sodium borohydride → HCID 58460153, compound

Participants

Reaction Steps

Sodium borohydride (158 mg) was added to a stirred solution of Intermediate 33 (421 mg) in dichloromethane (3 ml) and methanol (3.00 ml). The reaction mixture was stirred for 16 hours. The reaction mixture was concentrated under vacuum, partitioned between EtOAc (40 ml) and water (40 ml). The two phases were separated and the aqueous phase was extracted again with EtOAc (30 ml). The phases were separated, the organic extracts were combined, dried (hydrophobic frit) and concentrated under vacuum to give the required product (404 mg). LC/MS MH+ 305, Rt 2.59 min (5 minute run).

Provenance & Evidence