Methanesulfonyl chloride → HCID 58460218, compound

Participants

Reaction Conditions

Reaction Steps

Mesyl chloride (0.874 mL) was added dropwise to a suspension of Intermediate 40 (2.98 g) in dichloromethane (100 mL) at 0° C. under N2. Once addition was complete, the reaction was allowed to stir at 0° C. for a further 30 minutes before the bath was removed and the solution warmed to RT. The reaction mixture was quenched with water, and the aqueous extracted with DCM. The combined organics were passed through a hydrophobic frit and concentrated under reduced pressure, azeotroped with MeOH and dried on the high-vac to give the title compound 3.44 g. LC/MS MH+ 397, Rt 1.78 min (5 minute run).

Provenance & Evidence