Sodium Cyanide → HCID 58460221, compound

Participants

Reaction Steps

Intermediate 41 (3.8 g) and sodium cyanide (1.41 g) was dissolved in dimethyl sulfoxide (20 mL) and the mixture was stirred at 60° overnight. The reaction was stopped (only 1 g nitrile required) and cooled to RT before diluting with water/DCM. The aqueous was further extracted with DCM, and the combined organic extracts were passed though a hydrophobic frit, reduced in volume in vacuo, and the residue purified by flash column chromatography (0-15% MeOH in DCM, silica, repeated chromatography required). The appropriate fractions were combined to give the title compound (1.57 g).

Provenance & Evidence