2,4-Dichlorobenzylamine → HCID 58460196, compound

Participants

Reaction Conditions

Reaction Steps

2,4-dichlorobenzyl amine (0.080 mL), isovaleraldehyde (0.046 mL), ammonium acetate (38.5 mg), Intermediate 45 (99 mg) and acetic acid (0.143 mL) were mixed in chloroform (1 mL) and heated to 140° C. (Biotage Initiator) for 20 minutes. The mixture was purified by MDAP (Method C). The appropriate fractions were passed through SCX (5 g) and washed with methanol. The products were collected by elution in 2M ammonia in methanol. Title compound (35 mg). LC/MS MH+ 409, Rt 2.38 min (5 min run, TFA modifier).

Provenance & Evidence