Methanol → HCID 67434996, compound

Participants

Reaction Steps

Intermediate 46 (35 mg) was dissolved in 2 ml of MeTHF. Potassium trimethylsilanoate (12.19 mg) was added and the mixture stirred at room temperature overnight. 2 ml further MeTHF was added to the reaction, followed by Methanol. 4 M equivalent of sodium hydroxide was added and the reaction stirred at 50° C. for 2 hours. The reaction mixture passed through an SCX ion exchange column (10 g) and eluted with 2M Ammonia and methanol. (28 mg). LC/MS MH+ 381, Rt 2.06 min (5 min run, TFA modifier).

Provenance & Evidence