Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propanal | HCID 527 | — |
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | Cyclopentanecarbaldehyde | HCID 70106 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | HCID 58460212 | HCID 58460212 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 58460181 | HCID 58460181 | — |
Reaction Steps
Intermediate 45 (0.396 g), ammonium acetate (0.154 g), 4-chloro-benzylamine (0.292 ml), were mixed in chloroform (2 mL), to this mixture was added cyclopentanecarbaldehyde (427 ul), propanal (0.144 ml), acetic acid (0.572 ml) and heated to 140° C. (Biotage Initiator) for 20 minutes. The compound was reduced in vacuo and purified with column chromatography. Title compound (170 mg). LC/MS MH+401, Rt 2.47 min (5 min run, TFA modifier).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399444B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-0374842ea80449dfbb5dcb303191c9cb |
|---|
| Source note | uspto-grants-2013_03 |
|---|
