Isobutyraldehyde → HCID 58460176, compound

Participants

Reaction Steps

Acetic acid (0.572 mL) and ammonium acetate (154 mg) were mixed, to this were added Intermediate 65 (521 mg), isobutyraldehyde (0.196 mL) and (1S)-1-(4-chlorophenyl)ethanamine (0.362 mL) in chloroform (1.5 mL) and heated to reflux overnight. The mixture was reduced in vacuo and purified by column chromatography (0-100% ethyl acetate in cyclohexane). The appropriate fractions were concentrated in vacuo to yield 171 mg of the title compound. LC/MS MH+ 452, Rt 3.50 mins (5 min system, High ph).

Provenance & Evidence